History: 60 year old male with history of diabetes and hypertension presents with chronic and acutely worsening shortness of breath.
The differential for honeycombing pattern is wide and includes entities such as usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP), among others. The pattern implies end stage lung disease. The diagnosis in this case was UIP, with no known cause. In this case, the term idiopathic pulmonary fibrosis (IPF) applies.